Programme

• Thursday
  24 March THU
  24 Mar
• Friday
  25 March FRI
  25 Mar
• Saturday
  26 March SAT
  26 Mar
• LIST OF
  POSTERS LIST OF
  POSTERS

• 16:00-16:05

  Welcome

  by Organising Committee

  16:05-17:30

  Session I - Cardiac metabolism

  Chairs: Coert Zuurbier (Amsterdam, Netherlands), Vasco Sequeira de Oliveira (Würzburg, Germany)

  Jeanine Prompers (Utrecht, Netherlands)

  Metabolic imaging of the myocardium with multi-nuclear magnetic resonance techniques

  Jan Dudek (Würzburg, Germany)

  Metabolic remodeling of Barths syndrome

  Miranda Nabben (Maastricht, Netherlands)

  Nutraceutical approaches in cardiovascular and metabolic diseases

  Marten Szibor (Jena, Germany)

  Oxygen availability modulates respiratory plasticity in the heart through assembly and disassembly of mitochondrial F1F0-ATPase

  17:30-19:00

  Keynote lectures and discussion:
  National and International trends in practicing science

  17:30-18:00

  Marcel Levi (Amsterdam, Netherlands)

  18:00-18:30

  Blanche Schwappach-Pignataro (Hamburg, Germany)

  18:30-19:00

  Discussion led by Tilman Hackeng

  19:00

  Day closure

• 9:00-10:30

  Session II - Post-translational and signaling mechanisms in CVD

  Chairs: Leon de Windt (Maastricht, Netherlands), Kristina Lorenz (Dortmund, Germany)

  Johannes Backs (Dusseldorf, Germany)

  Post-translational modifications talk and crosstalk to class IIa histone deacetylases

  Daan Westenbrink (Groningen, Netherlands)

  Ketone bodies for the failing heart: fuels that can fix the engine?

  Kristina Lorenz (Dortmund, Germany)

  Alternative strategies of beta-adrenoreceptor modulation in heart failure

  Joost Luiken (Maastricht, Netherlands)

  Palmitoylation in diabetic cardiomyopathy

  10:30-11:00

  Break

  11:00-12:30

  Session III - Young Investigator session

  Chairs: Marc van Bilsen (Maastricht, Netherlands), Larissa Fabritz (Birmingham, UK)

  Oscar Gutierrez-Gutierrez (Göttingen, Germany)

  Preclinical CRISPR treatments to correct Duchenne Muscular Dystrophy in patient-specific cardiomyocytes and tissues

  Swati Srivastava (Erlangen, Germany)

  Gpr126 is required for proper N-cadherin localization and myocardial Notch activity to attain trabecular identity

  Joana Alves da Silva (Maastricht, Netherlands)

  MicroRNA-199b plays a role in distinct molecular mechanisms governing LV and RV pathological remodeling

  Valentin Burkart (Hannover, Germany)

  Nonsense mediated decay factor UPF3B is associated with MYBPC3-haploinsufficiency in hypertrophic cardiomyopathy patients

  Edgar Nollet (Amsterdam, Netherlands)

  ‘Disentangling’ mitochondrial dysfunction in hypertrophic cardiomyopathy

  12:30-14:30

  Poster Session I (even numbers)

  14:30-16:00

  Session IV - Determinants of cardiomyopathy susceptibility

  Chairs: Frances de Man (Amsterdam, Netherlands), Nazha Hamdani (Bochum, Germany)

  Navin Suthahar (Groningen, Netherlands)

  Biomarkers and cardiovascular outcomes: sex and age matter

  Theresia Kraft (Hanover, Germany)

  Contractile imbalance among cardiomyocytes – causes and consequences

  Frits Prinzen (Maastricht, Netherlands)

  Gender differences in response to cardiac resynchronization therapy

  Soni Pullamsetti (Bad Nauheim, Germany)

  Genome-wide mapping of the epigenetic landscape in human pulmonary hypertension

  16:00-16:30

  Break

  16:30-18:00

  Session V - “Next gen” cardiac renewal and regeneration

  Chairs: Marie-Jose Goumans (Leiden, Netherlands), Felix Engel (Erlangen, Germany)

  Diederik Kuster (Amsterdam, Netherlands)

  Identifying novel modulators of relaxation in hypertrophic cardiomyopathy

  Robert Passier (Twente, Netherlands)

  Native cardiac environment - impact on engineering cardiac tissue

  Felix Engel (Erlangen, Germany)

  Microtubule organization and cell cycle control in cardiomyocytes

  Zhiyong Lei (Utrecht, Netherlands)

  Myocardial unloading and opportunities for myocardial regeneration

  18:00-18:45

  Keynote lecture

  Chair: Paula da Costa Martins (Maastricht, Netherlands)

  Serena Zacchigna (Trieste, Italy)

  Cardiac revascularization: state of the art and perspectives

• 9:00-10:00

  Session VI - Upcoming CVD treatments

  Chair: Uli Schotten (Maastricht, Netherlands), Christian Kupatt (Münich, Germany)

  Ed Eringa (Maastricht, Netherlands)

  Novel targets for alleviating MVD

  Kevin Vernooy (Maastricht, Netherlands)

  Electrical management of heart failure

  Thomas Thum (Hanover, Germany)

  Alternative strategies in cardiac preclinical research and new clinical trial formats

  10:00-11:30

  Poster Session II (odd numbers)

  11:30-13:00

  Session VII - Cardiac genetics

  Chairs: Eva van Rooij (Utrecht, Netherlands), Monika Stoll (Münster, Germany / Maastricht, Netherlands)

  Peter van Tintelen (Leiden, Netherlands)

  Phenotypic expression, natural history and risk stratification of non-desmosomal arrhythmogenic cardiomyopathy

  Lukas Cyganek (Göttingen, Germany)

  Intronic CRISPR repair in a preclinical model of Noonan syndrome-associated cardiomyopathy

  Paul Volders (Maastricht, Netherlands)

  Mutation location and IKs regulation in the arrhythmic risk of long QT syndrome type

  Benjamin Meder (Heidelberg, Germany)

  SLM2 is a novel cardiac splicing factor involved in heart failure due to dilated cardiomyopathy

  13:00-13:30

  YIA and Poster prize announcement
  DGJM 2023 Organization statement
  Closing statements

• All poster presentations will take place on Gather.Town. Detailed information about accessing this online platform is available to all participants through the myMCWG area.

  Posters will be on display for the entire duration of the meeting. Posters with an even number will be presented during Poster Session I (Friday, 25 March). Posters with an odd number will be presented during Poster Session II (Saturday, 26 March).

  P.1 Heidi Budde (Bochum, Germany)
  Untangling the stress and metabolic pathways associated with inflammation and oxidative stress in right and left ventricles of heart failure with preserved ejection fraction
  
  P.2 Shambhabi Chatterjee (Hannover, Germany)
  Telomerase is essential for differentiation of human iPSCs into cardiomyocytes
  
  P.3 Winnie Chua (Birmingham, United Kingdom)
  Dynamic changes of cardiovascular biomarkers after ablation for atrial fibrillation: Observations from AXAFA-AFNET5
  
  P.6 Giorgia D'Italia (Maastricht, The Netherlands)
  Platelet dysfunction in HFpEF patients: plasma and whole blood measurements
  
  P.7 Wouter Derks (Dresden, Germany)
  Cardiomyocyte renewal in the diseased and mechanically assisted human heart
  
  P.8 Inez Duursma (Amsterdam, The Netherlands)
  LINCing the nucleus: nuclear abnormalities and chromatin alterations in hypertrophic cardiomyopathy
  
  P.9 Rose Eghbalian (Heidelberg, Germany)
  NIMA-related kinase 9 (NEK9) is essential for cardiac function via binding to essential myosin light chain (ELC)
  
  P.10 Katja Gehmlich (Birmingham, United Kingdom)
  Crucial functions of alpha-actinin 2 in the embryonic heart
  
  P.11 Kamilla Gömöri (Bochum, Germany)
  Oxidative stress in volume overload induced hypertrophy in a rat model
  
  P.12 Roua Hassoun (Essen, Germany)
  Increased Ca²⁺/calmodulin-dependent protein kinase II and protein kinase G oxidation contributes to impaired sarcomeric proteins in volume overload induced hypertrophy
  
  P.13 Jana-Charlotte Hegenbarth (Maastricht, The Netherlands)
  Machine learning-assisted integration of transcriptomic data at single cell resolution identifies key cardiomyocyte maturation genes
  
  P.14 Melissa Herwig (Bochum, Germany)
  The impact of cGMP-PKG pathway modulation on titin phosphorylation and titin-based myocardial passive stiffness
  
  P.15 Jordy Kocken (Maastricht, The Netherlands)
  Living myocardial slices as a novel multicellular model to study rat right ventricle ex vivo
  
  P.16 Eliška Kohoutková (Dresden, Germany)
  Self-forming human heart organoids for the modelling of heart injury and regeneration
  
  P.17 Judith Montag (Hannover, Germany)
  Human pluripotent stem cell derived cardiomyocytes as a model for burst-like transcription in Hypertrophic Cardiomyopathy
  
  P.18 Marie Noormalal (Kiel, Germany)
  Regnase-1 overexpression as a gene therapeutic approach of Marfan syndrome
  
  P.19 Anca Remes (Kiel, Germany)
  Regnase-1 overexpression in lung endothelium decreases the severity of pulmonary hypertension in mice
  
  P.20 Claudia Sacchetto (Maastricht, The Netherlands)
  Comparison of a knock-in mouse and a hiPSC-based model of arrhythmogenic cardiomyopathy carrying the DSG2 p.Q558* mutation
  
  P.21 Gabriela Santos (Göttingen, Germany)
  Human cardiac fibroblasts autonomously remodel their environment according to the mechanical situation within the engineered tissue
  
  P.22 Francesco Schianchi (Maastricht, The Netherlands)
  The post translational-modification protein palmitoylation: a missing mediator in the development of cardiac lipid-induced insulin resistance
  
  P.23 Marcel Sieme (Bochum, Germany)
  Chronic monotherapy with soluble guanylyl cyclase stimulation prevents diastolic dysfunction via reducing oxidative and metabolic stress signals: Restoration of endothelial and cardiomyocyte function
  
  P.24 Hafiz Muhammad Danish Sultan (Amsterdam, The Netherlands)
  A novel insight: accumulation of amyloid deposits in Atrial Fibrillation
  
  P.25 Melina Tangos (Bochum, Germany)
  Blood plasma exosomes: isolation and incubation with cells of the cardiovascular system
  
  P.26 Stan van Wijk (Amsterdam, The Netherlands)
  DNA damage in cytoskeletal protein variant-induced atrial fibrillation: a guide to novel treatment and screening targets (DnAFiX)
  
  P.27 Leonoor Wijdeveld (Amsterdam, The Netherlands)
  The devil is in the details: metabolomics to characterise the stages of atrial fibrillation
  
  P.28 Myrthe Willemars (Maastricht, The Netherlands)
  Phosphatidylinositol 4-kinase IIIβ as a target to prevent cardiac hypertrophy-induced contractile dysfunction
  
  P.29 Fabian Witthoff (Hamburg, Germany)
  Modeling molecular disease mechanisms of the human PRKD1 G592R variant in hiPSC-derived cardiac organoids
  
  P.30 Anton Xu (Würzburg, Germany)
  Energetic and redox uncoupling in human cardiomyopathy: interplay between hypercontractility and oxidation of myofilament creatine kinase
  
  P.31 Saltanat Zhazykbayeva (Bochum, Germany)
  Endothelial and cardiomyocyte dysfunction in heart failure with preserved ejection fraction is attenuated via PDE9A inhibition